It seems quite challenging in tissue engineering to synthesize a base material with a range of essential activities, including biocompatibility, nontoxicity, and antimicrobial activities. Various types of materials are synthesized to solve the problem. This study aimed to provide the latest relevant information for practitioners about antibacterial scaffolds in dental tissue engineering. The PubMed search engine was used to review the relevant studies with a combination of the following terms as search queries: tissue engineering, scaffolds, antimicrobial, dentistry, dental stem cells, and oral diseases. It is noteworthy to state that only the terms related to tissue engineering in dentistry were considered. The antimicrobial scaffolds support the local tissue regeneration and prevent adverse inflammatory reactions,however, not all scaffolds have such positive characteristics. To resolve this potential defect, different antimicrobial agents are used during the synthesis process. Innovative methods in guided tissue engineering are actively working towards new ways to control oral and periodontal diseases.

Bacteriophages are viruses that infect bacteria, and are distinct from animal and plant viruses that could have either lytic or lysogenic cycle. Lytic phages known as candidates for phage therapy, since they rapidly replicate into their host and lyse them. Theoretically, phages have more than a few benefits over routine antibiotics. They are extremely specific for their targeted hosts and also are safe for human, because they have no activity against eukaryotic cells. Over this time, phages were used to treat various infections. Although, phages have a number of advantages over antibiotics, their industrial production as a commercial product ceased in most of the western European countries after the introduction of antibiotics. These days, by increasing of antibiotics resistance and inefficiency of antibiotics against bacterial biofilms, there is renewed global interest in phage applications as potentially powerful antibacterial agents. Different published paper through the world indicates bacteriophages could be recruited as suitable agent for therapeutic purposes in medicine and food industry. Therefore, here we tried to review most of these ideas about phage application as a rapid review.